Mykola Dzerzhynsky

Mykola Dzerzhynsky


Assistant Professor
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

Head of Department of Cytology, Histology and Developmental Biology
Taras Shevchenko national University of Kyiv, Kyiv (Ukraine)


Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

Participant of Scientific Research Internship Program
University of Salzburg (Austria)

Doctor of Biological Science
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

Cytological and hystilogical aspects of metabolic disorders

Research Fields:

Previous and Current Research

  1. Influence of hypothalamic monoaminergic systems on the reproductive system in normal conditions and stress.
  2. Neuroendocrine photorefractoriness mechanisms in birds.
  3. Influence of the pineal gland and melatonin on neuroimmunoendocrine system.
  4. The study of circadian rhythmicity of the reproductive system in dependence on hypothalamic monoaminergic systems.
  5. The study of the relationship of electrophysiological and morphological parameters of hypothalamic functional activity at various conditions of the reproductive system of birds.
  6. Kisspeptin and melatonin interaction in the regulation of reproductive function in the central (neuro-glial interactions in the hypothalamus) and peripheral (testis) levels.
  7. Nanoparticles impact on neuroendocrine system.

Research was conducted on birds (Gallus domesticus, Coturnix coturnix, Anser anser) and mammals (Rattus norvegicus). Much attention is paid to the study of control mechanisms of reproductive function at different levels of regulation. Studies have expanded understanding of the neuroimmunoendocrine system in different classes of vertebrates.

Future Projects and Goals

The study of morphological and functional changes in the early stages of developing metabolic syndrome (a model of obesity and diabetes) due to the induction of the activity of the nervous immune-endocrine system in animals of different ages, and the search for possible ways of therapy.

In particular:

  1. Characteristics of changes in the morpho-functional state of hypothalamic neurosecretory and glial cells in normal conditions and in the development of metabolic syndrome on a background of a different activity of the nervous-immune-endocrine system.
  2. Comparative analysis of the profile and activity of immune cells in the brain (microglia) and normal adipose tissue and under the development of metabolic syndrome and various neural activity-immune-endocrine system.
  3. Investigation of the influence of violations in epiphysis cyclic recurrence on manifestations of the metabolic syndrome.
  4. Analysis of the cellular composition changes of white and brown adipose tissue, the characteristics of adipocytes differentiation and transdifferentiation processes in the development of metabolic syndrome, inflammation, carcinogenesis.
  5. Assessing of the impact of nano-composite materials with adsorbed substances on the manifestations of the metabolic syndrome.

Selected Publications

Halenova T., Roslova N., Vareniuk I., Dzerzhynsky M., Savchuk O., Ostapchenko L., Prylutskyy Yu.I., Ritter U., Scharff P..
Hepatoprotective effect of orally applied water-soluble pristine C60 fullerene against CCl4-induced acute liver injury in rats.
RSC Advances. 2016. Published online 5 Oct 2016.

Dovbynchuk T.V., Zakordonets L.V., Putnikov A.V., Varenyuk I.M., Tyapko O,P Roslova N.M., Serhiychuk T.N., Lynchak O.V., Dzerzhinsky M.E., Beregova T.V., Tolstanovf H.M..
Transport of water through the epithelium of the colon of rats under the experimental dysbiosis.
Physiological J. (Ukraine).- 2015.- T. 61, 6.- S. 76-84.

Matvienko M.G., Pustovalov A.S., Dzerzhinsk N.E.
Age dynamics of cell reaction in the preoptic hypothalamic nucleus during melatonin administration with a special reference to blockade and activation of the kisspeptinergic system.
Adv Gerontol. 2014. Vol. 27, 1. P. 81-86.

Yaremchuk S.E., Varenyuk I. N., Pustovalov A.S, Dzerzhinsky M.E., Roslova N.M, Tkachenko AV..
Experimental study of the protective effect of the drug "Sinupret" on the cells of the mucous membrane of the nasal cavity.
Otolaryngology. East Evropa.- 2013.- 1.- pp 39-46.

Hurlenko T.N., Voronina O.K, Grischuk V.M., Tolstanova G.M., Dzerzhinsky M.E., Beregova T.V.
Changes of functioning of epithelium transport system and morphological parameters of the colon mucosa of rats with hypergastrinemia varying duration.
Physiol. zhurnal. - 2007.- T. 53, 3.- P. 23-30.

Dzerzhynsky M.E., Nuzhyna N.V., Vareniuk I.M..
Morphometrical studies of reproductive system of birds after treatment with dopamine receptor blockers and melatonin.
Reproductive Biology. 2006. Vol. 6, Suppl. 2. P. 8792.

Dzerzhynsky M.E., Gorelikova O.I., Pustovalov A.S.
The interaction of the thyroid gland, pineal gland and immune system in chicken.
Reproductive Biology. 2006. Vol. 6, Suppl. 2. P. 7985.

Dzerzhinsky M.E., Varenyuk I.M.
Effect of monoamines and testosterone on the hypothalamic-gonadal range of Japanese quail (electrophysiological and morphometric study).
Physiol. zhurnal.- 2001.- T. 47, 4.- P. 49-57.

Samiĭlenko S.P., Potiahaĭlo A.L., Stepaniuhin A.V., Bohdan T.V., Dzerzhynsky M.E., Hovorun D.M.
Specific interactions of isoguanine with the neutral and deprotonated carboxylic group of amino acids: results of model quantum chemical calculations.
. 2001. . 73, 3. . 147-151.