Natalia Kutsevol




Natalia Kutsevol

POSITION
Vice Dean (Research)

WORK EXPERIENCE
1984–1989
Enginer
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

1989–2002
Junior Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2002–2004
Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2004–2014
Senior Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2008–2014
The head of team «Branched polymers and nanosystems”
Taras Shevchenko national University of Kyiv, Kyiv (Ukraine)

2014–2015
Leading Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2015–Present
Vice Dean (Research), Leading researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

EDUCATION AND TRAINING

1978–1981
Preparatory cycle
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

1982–1983
Master degree in Polymer chemistry
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2002
Ph.D
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2006
Senior researcher
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2006–2007
Doctorate
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2013
Doctor of Chemical Science
Taras Shevchenko National University of Kiev, Kyiv (Ukraine) 

Branched polymers and Nanosystems

Research Fields:
Chemistry

Previous and Current Research

  • Main field of research 
    Water-soluble graft copolymers (branched polymers)
  • Other fields 
    Polymer complexes
  • Current research interest 
    Branched polyelectrolytes 
    Polyelectrolyte-metal complexes 
    Metal and metal-oxide nanoparticles synthesized in polymer templates 
    Polymers as nanovectors for  anticancer drug elivery 
    Water treatment of  system containing clay/heavy metal ions  using branched polymer flocculants 

Group leader Dr. Chem. Sci. Nataliya Kutsevol

   Our group is interested in synthesis and characterization of water-soluble biocompatible polymers of non-linear architecture. We are focused on fundamental aspects of synthesis and characterization of branched uncharged  polymers and polyelectrolytes in solution as well as stimuli responsible branched polymers  and  nanosystems synthesized in situ into these polymer matrices. We study the response of these complicated systems towards external stimuli ( pH, T  ...) and their applications mainly in biomaterials or drug delivery fields.

The team consists of 2  researchers, 2 technicians and about 6  PhD,  Bachelor and Master  students.

  Branched polymer matrices have various chemical nature and internal structure, higher local concentration of functional groups in comparison with their linear analogue, and they can be very efficient for designing of optimized nanocarriers-nanosystems for medical applications and for water treatment. We are working in collaboration with physicists and  biologists.


     


Figure 1. Nanosystems, synthesized into polymer matrices of varios atchitecture and internal structure.






Figure 2. Temperature modulated drug release with PNIPAM micelles and enhanced cellular adsorption with PNIPAM.

 A transition across the lower critical solubility temperature (LCST) causes the physical change.

Methodological and Technical Expertise

  • Chemical modeling of branched polymers
  • Synthesis of nanosystems into polymer matrices
  • All experimental approaches for  characterization of polymers of complicated internal structure and nanosystems: elastic and quasy elastic light scattering, size-exclusion chromatography, transmission electron microscopy, differential scanning calorimetry, viscometry, potentiometric titration etc.


 

Selected Publications

N.Kutsevol, T.Bezugla.
Insfuence of structural peculiarities of Dextran sylphate-g-polyacrylamide on flocculation phenomena.
Ecological Chemistry and Engineering, 2011. V.18, ¹2, C.252-256.(IF 0.706)

Bezuglyi M., Kutsevol N., Rawiso M., Bezugla T.
Water-Soluble Branched Copolymers Dextran-Polyacrylamide and Their Anionic Derivates as Matrices for Metal Nanoparticles In-Situ Synthesis.
Chemik 2012.- ¹8, V.66. P.862-867.

Kutsevol N., Bezugla T., Bezuglyi M., Rawiso M.
Branched Dextran-Graft-Polyacrylamide Copolymers as Perspective Materials for Nanotechnology.
Macromol. Symp. 2012. -V.317-318, Iss. 1.- P.82-90. (IF 0.913)

N. Kutsevol, M. Bezuglyi, M. Rawiso, T. Bezugla.
Star-like Destran-graft-(polyacrylamide-co-polyacrylic acid) Copolymers.
Macromol. Symp. 2014, 335, P.12-16.(IF 0.913)

M.Yu. Losytskyy, I.V. Madan, N.V. Kutsevol, M. M. Petrenko,V.M. Yashchuk .
Effect of Polyacrylamide and Dextran-Polyacrylamide Graft Polymers on Absorption and Fluorescence Spectra of Hematoporphyrin.
Mol. Cryst. Mol Liq., 2014, 589:1, 226-231. (IF 0.493)

N.V.Kutsevol, T.N. Bezuglaya, N. Yu. Bezuglyi.
Features of the intramolecular structure of branched polymer systems in solution.
Journal of Structural Chemistry. 2014. V.55, ¹3, Ð.575-587.(IF 0.536)

V. Chumachenko, N. Kutsevol, M. Rawiso,M. Schmutz, C. Blanck.
In situ formation of silver nanoparticles in linear and branched polyelectrolyte matrices using various reducing agent.
Nanoscale Research Letters. 2014, 9: 164.(IF 2.779)

N.V. Kutsevol, V.A. Chumachenko, M. Rawiso. V.F. Shkodich, O.V. Stoyanov.
Star-like polymers dextran-polyacrylamide: the prospects of application for nanotechnology.
Journal of Structural Chemistry. 2015.V.56, ¹5. Ð.1016-1023. (IF 0.536)

Leonid Bulavin, Nataliya Kutsevol, Vasyl Chumachenko, Dmytro Soloviov, Alexander Kuklin, Andriy Marinin.
SAXS combined with UV-vis spectroscopy and QUELS: accurate characterization of silver sols synthesized in polymer matrices.
Nanoscale Research letters. 2016. 11:35. (IF 2.584)

Yeshchenko, O.A., Kutsevol, N.V., Naumenko, A.P.
Light-Induced Heating of Gold Nanoparticles in Colloidal Solution: Dependence on Detuning from Surface Plasmon Resonance 2016.
Plasmonics. 11 (1). P. 345–350. (IP 2.238)

N. Kutsevol, V. Chumachenko, M. Rawiso, A. Shyichuk.
Green synthesis of silver nanoparticles using glucose as reducing agent and dextran-graft-polyacrylamide as template.
Micro & Nano letters, 2016, V.11, Issue 5, P. 256-259. (IP 0.853)

V. A. Chumachenko, A. P. Naumenko, O. A. Yeshchenko, N.V. Kutsevol, I.S. Bondarchuk
Synthesis, morphology and optical properties of Au/Cds hybride nanocomposites stabilized by branched polymer matrices.
Journal of Nanomaterials. 2016. Volume 2016. Article number 1439437. (IF 1.644)

P. Telegeeva, N. Kutsevol, S. Filipchenko, G. Telegeev.
Dextran-Polyacrylamide as Nanocarrier for Targeted Delivery of Anticancer Drugs into Tumor Cells.
In Book “Chemical Engineering of Polymers Production of Functional and Flexible Materials”, Eds. O.V. Mukbaniany, M.J. Abadie, T. Tatrishvili. Part 2, Chapter 15. 396 p.

V. A. Chumachenko, I. O. Shton, E. D. Shishko, N. V. Kutsevol, A. I. Marinin and N. F. Gamaleia.
Branched Copolymers Dextran-Graft-Polyacrylamide as Nanocarriers for Delivery of Gold Nanoparticles and Photosensitizers to Tumor Cells.
Ñhapter in the Book: Nanophysics, Nanophotonics, Surface Studies, and Applications, 2016. Volume 183 of the series Springer Proceedings in Physics/ pp 379-390. Eds:Olena Fesenko, Leonid Yatsenko

Contacts

Homepage: http://macrochem.univ.kiev.ua/pages/history/history.html


kutsevol@ukr.net