Natalia Kutsevol




Natalia Kutsevol

POSITION
Vice Dean (Research)

WORK EXPERIENCE
1984–1989
Enginer
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

1989–2002
Junior Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2002–2004
Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2004–2014
Senior Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2008–2014
The head of team «Branched polymers and nanosystems”
Taras Shevchenko national University of Kyiv, Kyiv (Ukraine)

2014–2015
Leading Researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2015–Present
Vice Dean (Research), Leading researcher
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

EDUCATION AND TRAINING

1978–1981
Preparatory cycle
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

1982–1983
Master degree in Polymer chemistry
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2002
Ph.D
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)

2006
Senior researcher
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2006–2007
Doctorate
Taras Shevchenko National University of Kiev, Kyiv (Ukraine)

2013
Doctor of Chemical Science
Taras Shevchenko National University of Kiev, Kyiv (Ukraine) 


Branched polymers, pH and thermosensitive nanosystems for biomedical application

Research Fields:
Chemistry

Previous and Current Research

We are focused on fundamental aspects of synthesis and characterization of branched uncharged polymers, polyelectrolytes and stimuli responsible branched polymers in solution as well as hydrogels and nanosystems synthesized in situ into these polymer matrices. We study the response of these complicated systems towards external stimuli ( pH, T ...) and their applications mainly in biomaterials or drug delivery fields.

Branched polymer matrices have various chemical nature and internal structure, higher local concentration of functional groups in comparison with their linear analogue, and they can be very efficient for designing of optimized nanocarriers-nanosystems for medical applications and for water treatment. We are working in collaboration with physicists and biologists.

Figure 1. Nanosystems, synthesized into stimuli responsible polymer matrices of varios atchitecture and internal structure.

Figure 2.Temperature and pH-modulated drug release with polymer nanocarrier and enhanced cellular adsorption with polymer nanosystems.

Nanosystems for Photodynamic Therapy

Hydrogels for biomedical applications (PhD Nadtoka O)

It was shown that structure of hydrogels prepared by cross-linking of Dextran-graft-Polyacrylamide during synthesis had more possibility of Which?variation in comparison with cross-linked Polyacrylamide[12-13]. Polymeric hydrogels are used for biomedical applications as wound of various genesis dressing, artificial burn dressings, tissue technology, and water purification etc. [2]. The efficiency of such materials can be improved by incorporation of silver nanoparticles (AgNPs) which exhibit high antibacterial activity [3-4]. Size, size distribution (polydispersity), morphology, and surface charge of silver nanoparticles determine its biological activity [1] and are strongly dependent on the method of nanoparticles synthesis.

In the present work, we describe a new approach for synthesis and characterization of hydrogels based on cross-linked Dextran-graft-Polyacrylamide copolymers in non-ionic and anionic form with incorporated silver nanoparticles (AgNPs). 


Collaboration:
  • Institute  Charles Sadron,Strasbourg, France  (Dr. Michel Rawiso)
  • Kavetsky Institute of  Experimental Pathology, Oncology and Radiobiology, NASU  (Academician V.F. Chekhun)
  • Belarussian State University  (Dr. Vladimior Zorin)
  • Iv.-Frankivsk National Medical University (Prof. Krisa)
  • B.I. Verkin Institute for Low Temperature Physics and nd Engineering, NASU (Corr. Member  V.O. Karatchevtsev)
  • ISMA NASU Bogomoletz Institute of Physiology
 
Projects
2005-2006  NATO grant ESCCBR/NUKR.CLG 981343
2004-2006 Ukrainian-French project  DNIPRO
2011-2012 NATO grant ESC(2010)0064 CBR/NUKR.CLG 984
2012-2015 Development of nanostructures for target drug delivery into cells with
phagocytic activity – therapy of leukemia” (Academy of Science, Ukraine).Collaboration with the Institute of Molecular Biology and Genetics
2017-2018 Physical mechanisms of oxygen excitation in nanosystems for medical application”(Academy of Science and Ministry of Education, Ukraine)
2017-2018
2019-2020
Novel Hybrid Nanocomposites  for light-triggered and medicamental antitumor therapy” (State Fund for Fundamental Research of Ukraine)
Design and physico-chemical properties of novel multicomponent nanosystems for the treatment and diagnostics of solid tumors” Ukrainian-Republic of Belarus project
   

 
Fellowships
2002-2003 Post doctoral fellow (From 1st June until 31th December): Institut Charles Sadron, 
Strasbourg, France, Dr. J.-M. Guenet
2004-2008 Institut Charles Sadron, Strasbourg, France (1-3  months per year), Dr. J.-M. Guenet
2011-2012 Institut Charles Sadron, Strasbourg, France (1 month per year), Dr. M. Rawiso
2015 Contract, Project “Polyelectrolyes in ionic liquids”, Dr. M.Rawiso, Institute Charles Sadron, France (19.01.2015-19.02.2015).
2016 Grant for Scientific training for advanced scientists (French Embassy of Ukraine)
2017 Erasmus Plus Program, Strasbourg University, Faculty of Chemistry and Faculty of Physics
2019 Erasmus Plus Program, Strasbourg University, Faculty of Chemistry and Faculty of Physics

 
Other Activities
2011-2012 International Scientific Committee of the International IUPAC Conference
on Polymer-Solvent Complexes and Intercalates  “POLYSOLVAT” and Head of the
Organizing Committee from Department of Chemistry for “POLYSOLVAT 9” (11-14
 September 2012, Kyiv)
2013 Invited lecturer, Workshop NATO-Ukraine, 9th November, Kharkiv, Ukraine
2013 Invited lecturer, International scientific school “Polymers in medicine”, 27th May-1st June, Kazan, Russia
2013 Invited lecturer, International scientific school “Macromolecular chemistry”, 23-27th 
December,    Kazan, Russia
2016; 2018 Co-chairmen and Chairmen  of the 10 and 11-th International Conference «Electronic processes in organic and inorganic materials» (ICEPOM–10),
2016- till  now
 
Responsible for Erasmus Plus program for academic mobility between Taras Shevchenko national University and Strasbourg University (Faculties of Chemistry)
2018 The member of  the Expert commission: 10.04.2018, Institute of Scintillation Materials 
NASU
2018 Invited lecturer, International Scholl for Young Scientists “Functional Materials for        
Technical and Biomedial Application”, Kharkiv, 5-8 of September
2018 Invited  lecturer, Scientific and Practical Conference “Application of lasers in medicine  
and biology and 2nd Gamaleia’s Readings. 3-7 October 2018, Haiduszoboslo, Hungary
2019 Invited lecturer, The 1st Symposium of China-Ukraine NanoCarbon Black Joint Researcher Centre, Guangxi, Yulin. China, March 3-10, 2019.
2019 Administrative manager of Common Master programs “Physical Chemistry and materials” and “PopyS” between Taras Shevchenko            
National University and Strasbourg University (Faculties of Chemistry and Physics)

Member of the Editorial board of the Journal “Functional materials” (Scopus)

Methodological and Technical Expertise

  • Chemical modeling of branched polymers
  • Synthesis of nanosystems into polymer matrices
  • All experimental approaches for  characterization of polymers of complicated internal structure and nanosystems: elastic and quasy elastic light scattering, size-exclusion chromatography, transmission electron microscopy, differential scanning calorimetry, viscometry, potentiometric titration etc.

The team:

Chemists:

PhD V. Chumachenko

PhD student Yu. Harahuts

PhD O. Nadtoka

Biologist:

PhD P.Virych

 In collaboration with Physicists:

PhD A. Naumenko

Dr.Sci. O.Yeshchenko


Selected Publications

1.    Leonid Bulavin, Nataliya Kutsevol, Vasyl Chumachenko, Dmytro Soloviov, Alexander Kuklin, Andriy Marinin. SAXS combined with UV-vis spectroscopy and QUELS: accurate characterization of silver sols synthesized in polymer matrices. Nanoscale Research letters. 2016. 11:35.

2.    N. Kutsevol, V. Chumachenko, M. Rawiso, A. Shyichuk. Green synthesis of silver nanoparticles using glucose as reducing agent and dextran-graft-polyacrylamide as template. Micro & Nano letters, 2016, V.11, Issue 5, P. 256-259.

3.    V. A. Chumachenko, I. O. Shton, E. D. Shishko, N. V. Kutsevol, A. I. Marinin and N. F. Gamaleia. Branched Copolymers Dextran-Graft-Polyacrylamide as Nanocarriers for Delivery of Gold Nanoparticles and Photosensitizers to Tumor Cells. Ñhapter in the Book: Nanophysics, Nanophotonics, Surface Studies, and Applications, 2016. Volume 183 of the series Springer Proceedings in Physics/ pp 379-390.  Eds:Olena Fesenko, Leonid Yatsenko

4.    V. Chumachenko, N. Kutsevol, Yu. Harahuts, M. Rawiso, A. Marinin, L. Bulavin. Star-like Dextran-graft-PNiPAM copolymers. Effect of internal molecular structure on the phase transition. Journal of Molecular Liquids. 2017. V.235, P.77-82.

5.    G. Telegeev, N. Kutsevol, V. Chumachenko, A. Naumenko, P. Telegeeva, S. Filipchenko, and Yu. Harahuts. Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite. International Journal of Polymer Science. 2017.  Article ID 4929857.

6.    Oleg A. Yeshchenko, Antonina P. Naumenko, Nataliya V. Kutsevol, Daria O. Maskova, Iulia I. Harahuts, Vasyl A. Chumachenko, Andrey I. Marinin. Anomalous Inverse Hysteresis of Phase Transition in Thermosensitive Dextran-graft-PNIPAM Copolymer/Au Nanoparticles Hybrid Nanosystem. J. Phys. Chem. C, 2018, 122 (14), pp 8003–8010.

7.    N. Kutsevol, A. Glamazda, Chumachenko,Yu. Harahuts, S. G. Stepanian, A. M. Plokhotnichenko, V. A. Karachevtsev. Behavior of hybrid thermosensitive nanosystem dextran-graft-pnipam/gold nanoparticles: characterization within LCTS. Journal of Nanoparticle Research.2018.  J Nanopart Res (2018) 20: 236.

8.    Tatiana Matvienko, Viktoriya Sokolova, Svitlana Prylutska, Yuliia Harahuts, Nataliya Kutsevol, Viktor Kostjukov, Maxim Evstigneev, Yuriy Prylutskyy, Matthias Epple, Uwe Ritter. In vitro study of the anticancer activity of various Doxorubicin-containing dispersions. Bioimpacts. 2019;9(1):59-70.

9.    O. Nadtoka, N. Kutsevol,·A. Naumenko, P. Virych. Photochemical synthesis and characterization of hydrogel–silver nanoparticle composites. Research on Chemical Intermediates. 2019.

10. N. Kutsevol, A. Naumenko, Yu. Harahuts, V. Chumachenko, I. Shton, E. Shishko, N. Lukianova, V. Chekhun. New hybrid composites for photodynamic therapy: synthesis, characterization and biological study.  Appl Nanoscience. 2019. 9: 881. 

(Scopus) Kutsevol, Nataliya V. Author ID: 6603211250


Contacts

Homepage: http://macrochem.univ.kiev.ua/pages/history/history.html


kutsevol@ukr.net